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KMID : 0359920060250050823
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Korean Journal of Nephrology
2006 Volume.25 No. 5 p.823 ~ p.828
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A Case of Collagenofibrotic Glomerulopathy with Characteristic Electron Microscopic and Immunohistochemistry Findings
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Kim Chi-Weon
Kim Yon-Su
Moon Kyung-Chul
Kim Hyo-Sang
Cha Ran-Hui
Kim Sun-Moon
Oh Kook-Hwan
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Abstract
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Collagenofibrotic glomerulopathy is a relatively rare glomerular disease characterized by the accumulation of spiraled frayed collagen fibrils in mesangial and subendothelial areas. Clinically, patients with the disease usually present with moderate proteinuria and edema. They tend to have hypertension and their renal function deteriorates slowly. We report the case of a patient with collagenofibrotic glomerulopathy who also had Takayasus arteritis and presented with hypertension, proteinuria and dyspnea on exertion. Electron microscopy of the renal biopsy revealed massive accumulation of peculiar collagen fibers and immunohistology using monoclonal antibodies to collagen type III revealed positive stain in glomerular tufts. (Korean J Nephrol 2006;25(5): 823-827)
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KEYWORD
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Collagenofibrotic glomerulopathy, Type 3 collagen
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